In an attempt to get the offense going, Jerry Manuel showcased another new lineup, with Brian Daubach and Armando Rios playing for Paul Konerko and Frank Thomas, and the top three in the batting order being Willie Harris, D'Angelo Jimenez and Jose Valentin.
It didn't pay off at all in the first three innings as Meche retired the Sox nine straight. The Sox finally had their first hit and baserunner in the fourth, a Jimenez single, and put their first run up the next inning with a Carlos Lee solo home run.
The homer, Lee's seventh of the year, came two innings after Ichiro Suzuki hit a solo home run of his own, leading off the third. Lee went 2-4 and now has 21 RBIs, which is second on the team next to Magglio Ordonez (25), who had a strong day of his own, going 1-4 with a key two-run, game-tying double.
The double came in the sixth inning, after Miguel Olivo and Jimenez singled. With men on first and second, Ordonez hit a liner, splitting Mike Cameron and Suzuki in right-center field. Suzuki dropped the ball as he was trying to throw the ball in, allowing Ordonez to reach third.
Colon settled down after early troubles, allowing just three baserunners on two hits and a walk up through the eighth inning. Colon started the ninth, up 4-3, but a leadoff single by Edgar Martinez put Colon out of the game as he was replaced by Damaso Marte.
Martinez was pinch-ran for by Willie Bloomquist, who stole second after John Olerud flied out to center for the first out. Cameron then hit a soft sinking liner to Lee, who missed on a diving attempt but managed to catch it on a bounce and get it back to the infield to catch Bloomquist in a rundown for the second out. Marte then struck out pinch-hitter Greg Colbrunn to end it.
The fourth and eventual game-winning run scored by the Sox came in seventh. Lee led off with an infield single and advanced to third on a Daubach single to right. With men on the corners, Joe Crede hit into a double play, scoring Lee from third.
Harris, who showed good range in center field, went 1-4. Jimenez went 2-4 with a run scored, and Daubach went 2-4 while playing first and batting seventh. Crede and Olivo both went 1-4, while Rios and Valentin each went hitless, 0-4.
Valentin left a total of four men stranded.
Colon's line for the night was eight innings, three runs, six hits, two walks and four strikeouts on 116 pitches. He is now 3-3 with a 4.23 ERA. Meche gave up four runs in seven innings, picking up his second loss.
The Sox will play the rubber-game of the set on Sunday at 3:05 p.m. CT. Mark Buehrle is scheduled to pitch against fellow lefty Jamie Moyer. The game will be televised on Fox Sports Net Chicago.