Loaiza, who gave up five runs (4 earned) over seven innings, suffered his third loss of the season, raising his league-low ERA of 1.99 to 2.18. It was just the second time Loaiza gave up more than three runs in an outing.
Loaiza wasn't at his best, but still managed to keep the Cubs off the board until the fourth. By then, he was up 1-0 on a Jose Valentin RBI-sacrifice fly, scoring Magglio Ordonez, who walked and advanced to third on a single by Carlos Lee.
The Cubs scored in the fourth on a two-run homer by Moises Alou, and three batters later, on a Tom Goodwin RBI-single.
The lead was pushed to 4-1 after a D'Angelo Jimenez throwing error on a double play attempt, putting runners on the corners, and setting up a fielder's choice groundout by Corey Patterson. Jimenez, who was playing third base, committed another error in the seventh inning when a groundball hit by Patterson went off his glove. Jimenez went 0-2 with two walks.
Aaron Rowand -- Saturday's game-tying hero -- hit his third homer of the season, cutting the deficit to 4-2. The Cubs responded with a homer of their own in the sixth, by Jose Hernandez.
Wood ran into some trouble in both the seventh and eighth innings; loading the bases with one out in the seventh, and putting two men on with one out in the eighth. Both threats ended with a strikeout and popout.
Lefty Mark Remlinger recorded the first out of the ninth, while Joe Borowski finished it.
After Loaiza's seven innings, Rick White came in to throw two scoreless innings for the second straight game. White, who had a rough start to the season, has given up just two runs over his last 13 1/3 innings.
Of the White Sox' five hits, four came from Rowand and Lee, who had two each. Frank Thomas went 1-4, and the rest of the lineup was 0-19.
With the Royals loss and Twins win, the White Sox are now 4.5 games behind both teams as they get set to host the Twins for a three-game set starting Monday at 7:05 p.m. CT. Jon Garland is scheduled to pitch against Joe Mays. The game will be televised on WCIU.